abstract：:The possible association between cigarette smoking and the risk of benign breast disease (BBD) was assessed in a case-control study conducted in Gdańsk, Poland, between 1990 and 1994. The study compared 160 women with newly diagnosed BBD admitted to the Gdańsk Cancer Outpatients Clinic and 160 controls, women from out...

journal_title：Neoplasma

authors： Dziewulska-Bokiniec A

更新日期：1995-01-01 00:00:00

abstract：:Double immunofluorescence studies using both surface and cytoplasmic antigens were performed on cells of some human hematopoietic lines. We tested several permeabilization protocols in order to optimize, improve and simplify flow cytometric assay to detect the combinations of two markers present in one cell which coul...

journal_title：Neoplasma

authors： Koníková E,Kusenda J,Babusíková O,Glasová M

更新日期：1995-01-01 00:00:00

abstract：:The phorbolester (TPA)-induced homotypic aggregation of human monoblastoid U-937 cells was completely abolished by staurosporine, but not by a new selective protein kinase C inhibitor, benzoylated staurosporine derivative CGP 41,251, a compound with known anti-tumor and drug resistance modulating activity. Staurospori...

journal_title：Neoplasma

authors： Sedlák J,Sulíková M,Hunáková L,Chorváth B

更新日期：1995-01-01 00:00:00

abstract：:Therapeutic effect of Cyclophosphamide (CPA) and radiosensitizer AK-2123 (AK) combination versus CPA alone in the same doses was investigated on transplanted LL carcinoma and B 16 melanoma. Antimetastatic efficacy of different doses of CPA and combined therapy was evaluated. Our data demonstrate that the effect of com...

journal_title：Neoplasma

authors： Konovalova NP,Diatchkovskaya RF,Volkova LM,Kagiya TV

更新日期：1995-01-01 00:00:00

abstract：:DNA-mediated introduction of genes into mammalian cells promises to be a powerful method for detecting sequences that control cell growth, confer resistance to toxic drugs, code for surface receptor proteins, or, indeed alter cell phenotype in any clearly defined way. The identification and molecular cloning of human ...

journal_title：Neoplasma

authors： Sláviková K,Massouridou E

更新日期：1995-01-01 00:00:00

abstract：:The influence of two kinds of transplantable melanomas on the secretory function of peritoneal macrophages, and particularly the release of TNF-alpha has been studied. The results showed a statistically significant increase of protein content in the supernatants from 24 h cultured macrophages from melanoma-bearing ham...

journal_title：Neoplasma

authors： Kozłowska K,Cichorek M

更新日期：1995-01-01 00:00:00

abstract：:Possibilities of combined radioprotection, using preirradiation WR-2721 administration and post- or preirradiation Broncho-Vaxom administration in lethally whole-body gamma-irradiated mice were investigated. Combined modality treatments were more effective than individual treatments alone. The ameliorative influence o...

journal_title：Neoplasma

authors： Macková NO,Fedorocko P

更新日期：1995-01-01 00:00:00

abstract：:Sixty-three locoregional breast cancer biopsies were examined for association among epidermal growth factor receptors (as parameter of autocrine growth control), and estrogen and progesterone receptors (as endocrine parameters of estrogen responsiveness). In the tumor group with similar steroid receptor levels, low (0...

journal_title：Neoplasma

authors： Nikolić-Vukosavljević D,Kanjer K,Branković-Magić M,Spuzić I

更新日期：1994-01-01 00:00:00

abstract：:Eighty-four biopsies derived from cervical tissues were analyzed for the presence of human papillomavirus (HPV) DNA types 6, 16 and 18 using Southern blot hybridization. HPV 6 was found in none of the cervical biopsies, and HPV types 16 and 18 were found in 44% of them. The rate of HPV 16/18 positive samples increased...

journal_title：Neoplasma

authors： Matulić M,Sorić J

更新日期：1994-01-01 00:00:00

abstract：:Effect of pentoxifylline (PTX) on vincristine (VCR) resistance of multidrug resistant L1210/VCR mouse leukemic cell line was studied. Reversal effect of PTX (in concentration 50-150 mg/l) on vincristine resistance, i.e. potentiation of vincristine cytotoxicity on L1210/VCR cells by PTX was found. PTX alone in the abov...

journal_title：Neoplasma

authors： Breier A,Barancík M,Stefanková Z,Uhrík B,Tribulová N

更新日期：1994-01-01 00:00:00

abstract：:Twenty-nine bilateral breast carcinoma patients were analyzed retrospectively. The incidence of bilateral carcinoma of the breast among unilateral breast cancer patients was approximately 2.4%. Median age was 46 years at the time of first cancer diagnosis (range 26-69 years). The majority of the lesions were invasive ...

journal_title：Neoplasma

authors： Engin K

更新日期：1994-01-01 00:00:00

abstract：:Vincristine sensitive (L1210) and resistant (L1210/VCR) L1210 mouse leukemia cells were studied from morphological and histochemical point of view. The morphological and histochemical findings reflected differences in membrane structure and in physiological state of sensitive and resistant cells. Numerous villous proj...

journal_title：Neoplasma

authors： Uhrík B,Tribulová N,Klobusická M,Barancík M,Breier A

更新日期：1994-01-01 00:00:00

abstract：:The clastogenic effects of N-nitrosodimethylamine (N-DMA) and dinitrosoglycolurile (DNSGU) were studied in the bone marrow of mice and in peripheral blood lymphocytes of cows. None of the tested compounds showed significant enhancement of chromosome aberrations at doses 1/2 LD50 and 1/10 LD50 in murine bone marrow cel...

journal_title：Neoplasma

authors： Siviková K

更新日期：1994-01-01 00:00:00

abstract：:The inhibition of incorporation of 3H-thymidine and the changes of the rate of nascent DNA chain elongation were investigated in CHO Chinese hamster cells treated with (S)-(3-hydroxy-2-phosphonomethoxypropyl) (HPMP) and N-(2-phosphonomethoxyethyl) (PME) derivatives of adenine (A), guanine (G) and 2,6-diaminopurine (DA...

journal_title：Neoplasma

authors： Stĕtina R,Votruba I,Holý A,Merta A

更新日期：1993-01-01 00:00:00

abstract：:To evaluate the diagnostic usefulness of simultaneous determinations of carcinoembryonic antigen (CEA), neuron specific enolase (NSE), chorionic gonadotrophin (HCG) and carbohydrate antigenic determinant 19-9 (CA 19-9), we studied 48 patients with small cell lung carcinoma (SCLC) and 15 with nonmalignant lung disease....

journal_title：Neoplasma

authors： Nikliński J,Chyczewska E,Furman M,Kowal E,Laudanski J,Chyczewski L

更新日期：1993-01-01 00:00:00

abstract：:A comparative study has been performed on the relationship between vitamin E and immunofunction in normal and malignant condition in human and murine systems. Further, the effects of supplemental vitamin E on tumor take, host survival and tumor growth have been studied in a transplantable lymphoma in mice. Vitamin E w...

journal_title：Neoplasma

authors： Dasgupta J,Sanyal U,Das S

更新日期：1993-01-01 00:00:00

abstract：:In our earlier report on circulating immune complexes (CIC) from sera of patients with Hodgkin's disease (HD), we demonstrated disease-associated increase in the intensity of a 40kD (pl 5.6) polypeptide in the CIC. In extension of these investigations, we now report that the 40kD moiety exists in CIC as a complex with...

journal_title：Neoplasma

authors： Nerurkar AV,Advani SH,Gothoskar BP

更新日期：1993-01-01 00:00:00

abstract：:In a series of 2038 paraproteinemic sera, 9 IgD paraproteins (0.44%) were found. Clinical diagnosis of all the 9 was multiple myeloma. One patient had an IgD-lambda plasmacytoma which developed into plasmocellular leukemia. Our series of IgD paraproteins consisted of 6 females and 3 males with a mean age of 58.5 years...

journal_title：Neoplasma

authors： Tichý M,Matĕja F,Urban P,Matuska M

更新日期：1993-01-01 00:00:00

abstract：:Phorbol ester (PMA) induced decrease in cell surface expression of CD4 antigen was potentiated on human monoblastoid cell line U-937 cultured and induced in protein-free culture medium. Down-regulation of the CD4 antigen was partially inhibited by the isoquinoline protein kinase inhibitor H7 and unaffected by the calm...

journal_title：Neoplasma

authors： Hunáková L,Sedlák J,Chorváth B

更新日期：1993-01-01 00:00:00

abstract：:There is some evidence that prostaglandin (PGE)-secreting cells may have a role in immunosuppression in cancer patients. In this work we investigated the effects of indomethacin--a PGE synthesis inhibitor, on PHA-induced lymphoproliferative response in vitro. Twenty patients with lung cancer before therapy were includ...

journal_title：Neoplasma

authors： Stanojević-Bakić N,Vucković-Dekić L,Susnjar S,Spuzić I

更新日期：1992-01-01 00:00:00

abstract：:Multiple ultrasonographic (USG) evaluations of abdomen were performed in 97 patients: 30 with Hodgkin's disease (HD), 60 with non-Hodgkin lymphomas (NHL) and 7 with primary gastric lymphoma (PGL) before or during chemo- or X-ray therapy. In 33% of HD patients USG was normal, while in 63% splenomegaly, in 40% hepatomeg...

journal_title：Neoplasma

authors： Wojnar J,Kalina Z,Stella-Hołowiecka B,Krawczyk-Kuliś M,Wróbel R,Hołowiecki J

更新日期：1992-01-01 00:00:00

abstract：:The supernatants collected from cisplatin, lipopolysaccharide (LPS), muramyl dipeptide (MDP) or recombinant interferon gamma (rIFN-gamma) treated non-adherent mononuclear cells (with NK cell activity) enhanced thymocyte proliferation by a submitogenic concentration of concanavalin A as compared to untreated nMNC. Supe...

journal_title：Neoplasma

authors： Sodhi A,Pai K

更新日期：1992-01-01 00:00:00

abstract：:Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed...

journal_title：Neoplasma

authors： Anghileri LJ,Martinez AC,Maleki P

更新日期：1992-01-01 00:00:00

abstract：:The effect of CMF (cyclophosphamide, methotrexate and 5-fluorouracil) or tamoxifen treatment on endocrine function was investigated in premenopausal and postmenopausal breast cancer patients. CMF therapy resulted in ovarian failure but pituitary and adrenal functions were unaffected in premenopausal patients. Although...

journal_title：Neoplasma

authors： Bhatavdekar JM,Shah NG,Patel DD,Karelia NH,Trivedi SN,Vora HH,Ghosh N,Giri DD,Balar DB

更新日期：1992-01-01 00:00:00

abstract：:Cytolytic activity of mineral oil elicited rat peritoneal macrophages activated by lipopolysaccharide (LPS) and/or rIFN-gamma, rIL-2, Zymosan and PMA (4-beta-phorbol-12-beta-myristate 13-alpha-acetate) was detected in the presence of various concentrations of L-arginine. This paralleled the NO2- production in the pres...

journal_title：Neoplasma

authors： Kusenda J,Kalafut F,Klobusická M,Novotná L

更新日期：1992-01-01 00:00:00

abstract：:The activities of alanyl aminopeptidase (AAP), arginyl aminopeptidase (RAP), alpha-glutamyl aminopeptidase (EAP) and angiotensin I-converting enzyme (ACE) were investigated in primary human lung tumors of different histological types and in matched lung parenchyma. In contrast to the studied aminopeptidases whose acti...

journal_title：Neoplasma

authors： Procházka J,Krepela E,Sedo A,Viklický J,Fiala P

更新日期：1991-01-01 00:00:00

abstract：:The direct effect of selected cytostatic drugs on natural killer (NK) cell activity was evaluated. Peripheral blood mononuclear cells from healthy donors were tested for their cytolytic activity in vitro in the presence of adriamycin, methotrexate, leucovorin, vincristin, cytosine arabinoside and teniposide. Most of t...

journal_title：Neoplasma

authors： Ujházy P,Babusíková O

更新日期：1991-01-01 00:00:00

abstract：:The distribution of peanut agglutinin (PNA) receptors, nonspecific cross-reacting antigen (NCA) molecule and 3-fucosyl-N-acetyllactosamine (FAL) in myeloid leukemic cells isolated by density gradient centrifugation was compared using immunofluorescence test (IF). Patients with acute myelocytic leukemias (AML) type M2 ...

journal_title：Neoplasma

authors： Noworolska A,Slesak B,Harłonzińska A,Richter R

更新日期：1991-01-01 00:00:00

abstract：:C-band heteromorphism was studied in 106 females, including 71 patients with breast cancer or ovarian cancer. Size heteromorphism and localization variants (inversions) were scored separately. Compared to 22.86% of controls, 70.42% of the cancer patients were heteromorphic for the size of C-band. The localization vari...

journal_title：Neoplasma

authors： Adhvaryu SG,Rawal UM

更新日期：1991-01-01 00:00:00

abstract：:A capture monoclonal antibody-based assay has been established for detecting the p24 core protein and the gp51 envelope glycoprotein of bovine leukemia virus (BLV). This assay is rapid, highly sensitive and specific. Viral antigens in test samples were identified using mouse monoclonal antibody-coated or microtiter pl...

journal_title：Neoplasma

authors： Bán J,Altanerová V,Orlík O,Altaner C

更新日期：1991-01-01 00:00:00

abstract：:The levels of carcinoembryonic antigen (CEA) and the activities of creatine kinase isoenzyme BB (CK-BB) were assessed in 84 patients with primary lung carcinoma and in 20 patients with nonmalignant lung diseases. The level of CEA was measured by the immunoenzymatic method using monoclonal antibodies (Abbott). The acti...

journal_title：Neoplasma

authors： Nikliński J,Furman M,Laudański J,Pałynyczko Z,Welk M

更新日期：1991-01-01 00:00:00

abstract：:The effect of oxoplatinum on blastic transformation of human peripheral blood mononuclear cells (PBMC) was monitored following phytohemagglutinin (PHA) stimulation. The results were compared with those published in part III of the present work as well as with the effect of cisplatinum and carboplatinum on the blastic ...

journal_title：Neoplasma

authors： Kanková-Vancurová M,Procházková J

更新日期：1991-01-01 00:00:00

abstract：:Acyclic nucleotide analogs (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) were phosphorylated in the presence of ribonucleoside 5'-triphosphates by the crude extract from mouse leukemia cells L1210 affording the respective mono- and diphosphoryl derivatives. T...

journal_title：Neoplasma

authors： Merta A,Veselý J,Votruba I,Rosenberg I,Holý A

更新日期：1990-01-01 00:00:00

abstract：:Sixty-five patients with Stage I and II endometrial carcinoma were investigated. After a short-time follow-up (17-24 months) significant differences in frequency of relapses were observed between patients with tumors containing low amounts of estrogen receptor (ER less than 60 fmol/mg DNA) in the nuclear pellet, and t...

journal_title：Neoplasma

authors： Horvath G,Johnsson JE,Tropé C,Samuelsson L,Alm P,Olsson H

更新日期：1990-01-01 00:00:00

abstract：:During the years 1973-1987, 75 patients were irradiated for brain metastases of unknown origin at the Institute of Oncology in Ljubljana. Of these, 35 (47%) were previously treated by surgery: Metastases were completely removed in 22 patients and partially in 7, whereas biopsy alone was performed in 6 patients. Based ...

journal_title：Neoplasma

authors： Debevec M

更新日期：1990-01-01 00:00:00

abstract：:In a series of 52 biopsy specimens (31 endometrial carcinomas, 10 atypical endometrial hyperplasias, and 11 cases of normal endometrium), DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded material. DNA aneuploidy was detected in 2 of the 10 atypical endometrial hyperplasias and 7 of the 31 endom...

journal_title：Neoplasma

authors： Kysela B,Siracký J,Redecha M,Bárdos A

更新日期：1990-01-01 00:00:00

abstract：:The cancer chemotherapeutic efficacy of 3,4-dihydroxybenzylamine (DHBA), a dopamine analog with reduced neurotoxic effects, was evaluated in strain A mice bearing transplantable Ehrlich's ascites carcinoma. The analog was administered intraperitoneally on day 1 post-transplantation at dose schedules of 50, 100 and 200...

journal_title：Neoplasma

authors： Lahiri T,Banerjee S,Dasgupta PS,Ray MR

更新日期：1990-01-01 00:00:00

abstract：:The response of different stages of spermatogenesis to heat have been assessed by scoring the cell types in testis tubules at 14, 28 and 35 days after treatment. Deficiencies in spermatids at these times can be related back to the stage that the precursor would have been in 14 and 28 days earlier. On the 35th day the ...

journal_title：Neoplasma

authors： Gasinska A,Hill S

更新日期：1990-01-01 00:00:00

abstract：:A report on 1877 consecutive node negative (N-) breast cancer cases is presented in which the prognostic value of the main clinico-pathologic features is evaluated. Tumor size (and UICC-TNM T category) and lobular infiltrating histologic type were significantly associated with a more favorable prognosis whereas no ass...

journal_title：Neoplasma

authors： Ciatto S,Cecchini S,Grazzini G,Iossa A,Bartoli D,Rasponi A

更新日期：1990-01-01 00:00:00

abstract：:The effects of 9-beta-D-arabinofuranosyladenine (araA) on radiosensitivity, postirradiation changes in the cell cycle distribution and DNA synthesis in mouse L5178Y-S lymphoma cells are described. Increase in the araA concentration (from 25 to 200 mumol/l) was is correlated with reduction in clonogenic survival except...

journal_title：Neoplasma

authors： Kapiszewska M,Lange CS

更新日期：1989-01-01 00:00:00